Most of those who contact me about this program have problems with the immune system, the GI tract or fatigue. Where nucleotides are critical components of energy transfer (such as ATP) and mitochondrial energy pathways (NADH, FAD as part of riboflavin, and Coenzyme A), the need for nucleotides is a consistent factor for those looking to support energy in their systems, particularly those individuals under chronic stress.
Perhaps one of the greatest positive impacts of nucleotides is on cells that need to be replenished on a regular basis. This would include those with health issues related to the gut and intestinal tract, those with immune system issues, those looking to repair injury. The rapidly growing cells of the immune system cannot fulfill the vast need for nucleotides from natural synthesis within the body and thus need additional dietary support. A series of articles from the University of Texas (Kulkarni, 1989; Rudolph, 1986; Van Buren, 1983) systematically illustrate the role of nucleotides in proper immune function. “Early studies using diets free of preformed nucleotides confirmed their role in immune function; the absence of nucleotides produced significant reductions in host immune responses, including downregulation of T cell function and antigen stimulation.” The absence of nucleotide support has also been reported to influence the level of the Helper T cell population and function; these Helper T cells are important in modulating the immune response to vaccination/antigens. This would support the observations of many using this program that have imbalances in antibody titers, and either a lack of proper immune responses or excessive immune responses to challenges with antigens. Additional research has elucidated a role for nucleotides in the differentiation of lymphocytes as well as their proliferation, aiding in a balanced and more optimal immune response. (Rudolph 1990). “Dietary nucleotides have been shown to have important effects on several components of the immune system: they may enhance intestinal absorption of iron; they affect lipoprotein and long-chain polyunsaturated fatty acid metabolism; they may alter intestinal flora; and they have been demonstrated to have trophic effects on the intestinal mucosa and liver in several experimental situations. Clinical studies have shown nucleotide supplementation of infant formula reduces the incidence of diarrheal episodes” (Cosgrove, 1998).
The number of references supporting the use of nucleotides is literally voluminous. A PubMed search of the term “nucleotides” pulls up 542,441 references. ‘Dietary nucleotide’ pulls up over 10,000 references and ‘RNA’ pulls up 872,347 citations. Needless to say it would be impossible to review all of that literature in this book. Instead I have tried to focus on the most relevant articles that tie directly to those using my program and their health concerns.